Volker Arnd Coenen, MD, Neurosurgeon from the University Medical Center Freiburg, Germany, presents how his institution is advancing workflows for deep brain stimulation (DBS) surgery and discusses current advanced imaging technologies. Specifically, he discusses tremor and in more detail the treatment of major depression. He then delves into how machine learning has aided personalized DTI tractographic planning for DBS of the superolateral Medial Forebrain Bundle (MFB) with hierarchical harmonic filters for learning tracts from diffusion MRI (HAMLET).